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Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication

5 Jun 2017

Abstract excerpt

) kinetic screening and analysis to find the scFvs that inhibit selectively the fibril-catalyzed secondary nucleation process in Aβ42 aggregation. By applying this approach, we have identified four scFvs that inhibit specifically the fibril-dependent secondary nucleation process. Our method also makes it possible to discard antibodies that inhibit elongation, an important factor because the suppression of...

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PMID: 28584111
DOI: 10.1073/pnas.1700407114

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