Article
"Two-in-One" approach for bioassay selection for dual specificity antibodies.
Journal of immunological methods - 1 Sept 2017
Lee Ho Young, Schaefer Gabriele, Lesaca Ingrid, Lee Chingwei Vivian, Wong Pin Yee, Jiang Guoying
Abstract excerpt
Dual specific antibodies and bispecific antibodies that recognize two different antigen targets are currently being regarded as very effective therapeutics for complex human diseases. While effective, designing and developing a bioassay strategy for dual specific antibodies that is reflective of the mechanism of action (MoA) and also measures the dual activities of antibodies pose unique and exciting challenges....
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