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Article

Single nucleotide variant in Nucleoporin 107 may be predictive of sensitivity to chemotherapy in patients with ovarian cancer.

Pharmacogenetics and genomics - 1 Jul 2017

Alanee Shaheen, Delfino Kristin, Wilber Andrew, Robinson Kathy, Brard Laurent, Semaan Assaad

Abstract excerpt

BACKGROUND: Alterations in nuclear pore complex (NPC) genes have been previously associated with response to chemotherapy. Using agnostic exome sequencing, we envisioned that new alleles in NPC genes, predictive of sensitivity to platinum treatment, could be discovered. METHODS: Twenty-two platinum-sensitive and six platinum-resistant ovarian cancer patients were tested. Platinum sensitivity was defined as...

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Identifiers

PMID: 28562428
DOI: 10.1097/FPC.0000000000000288
PMCID: PMC6298606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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