Article
Significance of EGFR Expression in Circulating Tumor Cells.
Advances in experimental medicine and biology - 1 Jan 2017
Serrano María José, Alvarez-Cubero María Jesús, De Miguel Pérez Diego, Rodríguez-Martínez Alba, Gonzalez-Herrera Lucas, Robles-Fernandez Inmaculada, Hernandez José Exposito, Puche Jose Luis García, Lorente José Antonio
Abstract excerpt
This chapter focuses on a deep description of the epidermal growth factor receptor (EGFR) expression in circulating tumor cells (CTCs) and its main role in cancer progression, genetic changes related to metastasis , and resistance to treatment. The aberrant behavior of cancer cells is caused by genetic mutations and altered patterns of gene expression. These changes can be responsible for an increase in cell...
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