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Crosstalk between autophagy and epithelial-mesenchymal transition and its application in cancer therapy

24 May 2019

Abstract excerpt

Autophagy is a highly conserved catabolic process that mediates degradation of pernicious or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and organelles. It can promote or suppress tumor development, so it is a "double-edged sword" in tumors that depends on the cell and tissue types and the stages of tumor. The epithelial-mesenchymal transition (EMT) is a complex biological...

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PMID: 31126310
DOI: 10.1186/s12943-019-1030-2

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