Article
Pigmented trichoblastoma developed in a sebaceous nevus: HRAS mutation as a common molecular driver.
Pathology, research and practice - 1 Jul 2017
Saraggi Deborah, Salmaso Roberto, Valentini Elisa, Munari Giada, Vindigni Vincenzo, Rugge Massimo, Fassan Matteo, Cerroni Lorenzo
Abstract excerpt
A 40-year-old woman presented with a pigmented nodule on a previously existing yellowish, verrucous plaque on the scalp. The histological diagnosis was consistent with a pigmented trichoblastoma developed within a sebaceous nevus (SN). A multigene hotspot mutational profiling of the BRAF, NRAS, HRAS and KRAS genes was carried out, and a shared G13R HRAS mutation in both the trichoblastoma and the sebaceous nevus...
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