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Article

Activating mutations in the RAS/mitogen-activated protein kinase signaling pathway in sporadic trichoblastoma and syringocystadenoma papilliferum.

Human pathology - 1 Feb 2015

Shen Anne-Sophie, Peterhof Eva, Kind Peter, Rütten Arno, Zelger Bernhard, Landthaler Michael, Berneburg Mark, Hafner Christian, Groesser Leopold

Abstract excerpt

Trichoblastoma (TB) and syringocystadenoma papilliferum (SCAP) are both rare adnexal skin lesions occurring either sporadically or as secondary neoplasms in sebaceous nevi. TB and SCAP associated with sebaceous nevi have been shown to carry the same HRAS mutation as the underlying nevus. However, the genetic background of sporadic TB and SCAP has remained unknown. Therefore, we screened 18 sporadic TBs and 23...

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Source

Identifiers

PMID: 25532942
DOI: 10.1016/j.humpath.2014.11.002

Genes

BRAF
SCAP
HRAS
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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