Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combined melanocytic and sweat gland neoplasm: cell subsets harbor an identical HRAS mutation in phacomatosis pigmentokeratotica.

Journal of cutaneous pathology - 1 Aug 2014

Li Janet Y, Berger Michael F, Marghoob Ashfaq, Bhanot Umesh K, Toyohara Jennifer P, Pulitzer Melissa P

Abstract excerpt

Phacomatosis pigmentokeratotica (PPK) is characterized by the co-existence of epidermal nevi and large segmental speckled lentiginous nevi of the papulosa type. PPK, previously explained as 'twin spot' mosaicism due to the postzygotic crossing-over of two homozygous recessive mutations, has recently been shown to derive from one postzygotic activating RAS mutation. Epidermal nevi, including those in PPK, are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Laser Capture Microdissection

Share to Melanoma

Share to Nevus, Pigmented

Share to Proto-Oncogene Proteins p21(ras)

Share to Skin Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 24628623
DOI: 10.1111/cup.12339
PMCID: PMC5175589

Genes

HRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combined melanocytic and sweat gland neoplasm: cell subsets harbor an identical HRAS mutation in phacomatosis pigmentokeratotica.PMID 24628623Read ↗

Phacomatosis Pigmentokeratotica: A Mosaic RASopathy with Malignant Potential.Semantic proximity Read ↗

Attempting to Solve the Pigmented Epithelioid Melanocytoma (PEM) ConundrumSemantic proximity Read ↗

Mosaic RASopathies: Comprehensive Genetic and Clinicopathological Analysis for Diagnosis and ManagementSemantic proximity Read ↗

Molecular pathology as a diagnostic aid in difficult-to-classify melanocytic tumours with spitzoid morphology.Semantic proximity Read ↗

Naevus sebaceus: a mosaic RASopathy.Semantic proximity Read ↗

Germline and somatic second-hit changes in porokeratosis: comprehensive variant spectrum and genotype-phenotype correlation analysis.Semantic proximity Read ↗

Epidermal, sebaceous, and melanocytic nevoid proliferations are spectrums of mosaic RASopathies.Semantic proximity Read ↗

Nevus sebaceus is a mosaic RASopathy.Semantic proximity Read ↗

Pigmented trichoblastoma developed in a sebaceous nevus: HRAS mutation as a common molecular driver.Semantic proximity Read ↗

Mosaic RASopathies concept: different skin lesions, same systemic manifestations?Semantic proximity Read ↗

Genetic and phenotypic diversities of nevus spilus phenotypes: Case series and a proposed diagnostic algorithm.Semantic proximity Read ↗

A possible role for second-hit postzygotic GJB2 mutation in porokeratotic eccrine ostial and dermal duct nevus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.