Article
Frequent activating HRAS mutations in trichilemmoma.
The British journal of dermatology - 1 Nov 2014
Tsai J-H, Huang W-C, Jhuang J-Y, Jeng Y-M, Cheng M-L, Chiu H-Y, Kuo K-T, Liau J-Y
Abstract excerpt
BACKGROUND: Trichilemmoma is a benign follicular epithelial tumour exhibiting outer root sheath differentiation. It is associated with Cowden syndrome and naevus sebaceus (NS), but the pathogenesis of sporadic tumours is poorly understood. Recently, NS was found to be caused by postzygotic HRAS or KRAS mutations. OBJECTIVES: We sought to determine whether NS-related and NS-unrelated trichilemmomas harbour RAS...
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