Article
Comprehensive Analysis of the Discordance of EGFR Mutation Status between Tumor Tissues and Matched Circulating Tumor DNA in Advanced Non-Small Cell Lung Cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Sept 2017
Wan Rui, Wang Zhijie, Lee J Jack, Wang Shuhang, Li Qingqing, Tang Fuchou, Wang Jin, Sun Yu, Bai Hua, Wang Di, Zhao Jun, Duan Jianchun, Zhuo Minglei, An Tongtong, Wu Meina, Chen Zhaoli, Yang Zhenlin, Wang Jie
Abstract excerpt
INTRODUCTION: This study aimed to address the underlying reasons for and clinical significance of the discordant EGFR mutation (EGFRm) status between tumor tissue (TT) and circulating tumor DNA (ctDNA). METHODS: Three groups of EGFR tyrosine kinase inhibitor (EGFR TKI)-treated patients whose EGFRm status was determined by the amplification refractory mutation system (ARMS) were included (group A,...
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