Article
Medullary thyroid carcinoma.
Clinical oncology (Royal College of Radiologists (Great Britain)) - 1 Aug 2010
Pacini F, Castagna M G, Cipri C, Schlumberger M
Abstract excerpt
Medullary thyroid carcinoma (MTC) accounts for 5-8% of all thyroid cancers. MTC is mainly sporadic in nature, but an hereditary pattern [multiple endocrine neoplasia type 2 (MEN 2)] is present in 20-30% of cases, transmitted as an autosomal-dominant trait due to germline mutations of the RET proto-oncogene. About 98% of patients with MEN 2 have germline mutations in exons 5, 8, 10, 11, 13, 14, 15 or 16 of the RET...
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