Article

General anaesthetics reduce acute lymphoblastic leukaemia malignancies in vitro and in vivo via CXCR4 and osteopontin mediated mechanisms

2025-10-09

Abstract excerpt

Background Acute lymphoblastic leukaemia (ALL) is a common type of cancer in children. General anaesthetics are often used on patients undergoing painful procedures during ALL treatments but their effects on ALL malignancy remain unknown. Herein, we aim to study the effect of propofol and sevoflurane on the migration, homing and chemoresistance of ALL cells. Methods NALM-6 and Reh cells were treated with propofol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6cee9b6e-8eb4-5575-905b-57520c3750bf
DOI: 10.12688/f1000research.125877.3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

General anaesthetics reduce acute lymphoblastic leukaemia malignancies in vitro and in vivo via CXCR4 and osteopontin mediated mechanismsDOI 10.12688/f1000research.125877.3Read

Molecular mechanisms and impact of anaesthetics on cancer cell biologySemantic proximity Read

Anesthetics may modulate cancer surgical outcome: a possible role of miRNAs regulationSemantic proximity Read

Molecular Aspect of Propofol's Effect on Cytotoxic and Long Non-Coding RNA (lncRNA) Expressions in MCF-7Semantic proximity Read

VERY EARLY REMISSION AND INCREASED APOPTOSIS WITH THE USE OF PENTOXIFYLLINE IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIASemantic proximity Read

Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancySemantic proximity Read

Heparan sulfate proteoglycan on leukemic cells is primarily involved in integrin triggering and its mediated adhesion to endothelial cells.Semantic proximity Read

Central nervous system involvement in acute lymphoblastic leukemia is mediated by vascular endothelial growth factorSemantic proximity Read

Taper up-off treatment of opium may reverse some dysregulations of gene expression patterns caused by four type of leukemia, AML, ALL, CML and CLL; a pilot animal model studySemantic proximity Read