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Article

Genetic basis of hypercholesterolemia in adults

14 Apr 2021

Abstract excerpt

We investigated monogenic and polygenic causes of hypercholesterolemia in a population-based cohort, excluding secondary hypercholesterolemia, and using an established framework to identify pathogenic variants. We studied 1682 individuals (50.2 ± 8.6 years, 41.3% males) from southeast Minnesota with primary hypercholesterolemia (low-density lipoprotein cholesterol (LDL-C) ≥155 mg/dl in the absence of identifiable...

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PMID: 33854068
DOI: 10.1038/s41525-021-00190-z

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