Article
Whole genome sequencing reveals within-host genetic changes in paired meningococcal carriage isolates from Ethiopia.
BMC genomics - 25 May 2017
Bårnes Guro K, Brynildsrud Ola Brønstad, Børud Bente, Workalemahu Bereket, Kristiansen Paul A, Beyene Demissew, Aseffa Abraham, Caugant Dominique A
Abstract excerpt
BACKGROUND: Meningococcal colonization is a prerequisite for transmission and disease, but the bacterium only very infrequently causes disease while asymptomatic carriage is common. Carriage is highly dynamic, showing a great variety across time and space within and across populations, but also within individuals. The understanding of genetic changes in the meningococcus during carriage, when the bacteria resides...
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