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Article

SUMO-4: A novel functional candidate in the human placental protein SUMOylation machinery

17 May 2017

Abstract excerpt

BACKGROUND: Small ubiquitin-like modifiers (SUMOs) conjugate to proteins post-translationally, thereby affecting target localization, activity and stability. Functional SUMO family members identified in the human placenta include SUMO-1 to SUMO-3, which are elevated in pre-eclampsia. Whether the fourth isoform, SUMO-4, plays a role in placental development and function remains unknown. OBJECTIVES: We tested the...

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PMID: 28545138
DOI: 10.1371/journal.pone.0178056

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