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Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa

17 Oct 2012

Abstract excerpt

BACKGROUND: Sumoylation is a type of post-translational modification that is implicated in the regulation of numerous cellular events. However, its role in the function of human sperm has not yet been characterized. METHODS AND RESULTS: In this study, both immunofluorescence and electron microscopy revealed that small ubiquitin-like modifiers (SUMO) SUMO1 and SUMO2/3 were highly enriched in the neck area of human...

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PMID: 23077236
DOI: 10.1093/humrep/des317

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