Article
Evidence for pleural epithelial-mesenchymal transition in murine compensatory lung growth.
PloS one - 1 Jan 2017
Ysasi Alexandra B, Wagner Willi L, Valenzuela Cristian D, Kienzle Arne, Servais Andrew B, Bennett Robert D, Tsuda Akira, Ackermann Maximilian, Mentzer Steven J
Abstract excerpt
In many mammals, including rodents and humans, removal of one lung results in the compensatory growth of the remaining lung; however, the mechanism of compensatory lung growth is unknown. Here, we investigated the changes in morphology and phenotype of pleural cells after pneumonectomy. Between days 1 and 3 after pneumonectomy, cells expressing α-smooth muscle actin (SMA), a cytoplasmic marker of myofibroblasts,...
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