Article
Contribution of Fetal, but Not Adult, Pulmonary Mesothelium to Mesenchymal Lineages in Lung Homeostasis and Fibrosis.
American journal of respiratory cell and molecular biology - 1 Feb 2016
von Gise Alexander, Stevens Sean M, Honor Leah B, Oh Jin Hee, Gao Chi, Zhou Bin, Pu William T
Abstract excerpt
The lung is enveloped by a layer of specialized epithelium, the pulmonary mesothelium. In other organs, mesothelial cells undergo epithelial-mesenchymal transition and contribute to organ stromal cells. The contribution of pulmonary mesothelial cells (PMCs) to the developing lung has been evaluated with differing conclusions. PMCs have also been indirectly implicated in lung fibrosis in the progressive, fatal...
Topics
- Animals
- Biomarkers
- Bleomycin
- Cell Lineage
- Cell Proliferation
- Cell Tracking
- Disease Models, Animal
- Epithelial-Mesenchymal Transition
- Fibroblasts
- Lung
- Mesoderm
- Mice, Transgenic
- Myofibroblasts