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Article

Mesenchymal stem cells in inflammation microenvironment accelerates hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition.

PloS one - 1 Jan 2012

Jing Yingying, Han Zhipeng, Liu Yan, Sun Kai, Zhang Shanshan, Jiang Guocheng, Li Rong, Gao Lu, Zhao Xue, Wu Dong, Cai Xiong, Wu Mengchao, Wei Lixin

Abstract excerpt

In response to inflammation, mesenchymal stem cells (MSCs) are known to migrate to tissue injury sites to participate in immune modulation, tissue remodeling and wound healing. Tumors apply persistent mechanical and pathological stress to tissues and causes continual infiltration of MSCs. Here, we demonstrate that MSCs promote human hepatocellular carcinoma (HCC) metastasis under the influence of inflammation....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22952657
DOI: 10.1371/journal.pone.0043272
PMCID: PMC3429457

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