Article
Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis.
Nature genetics - 1 Jan 2011
Painter Jodie N, Anderson Carl A, Nyholt Dale R, Macgregor Stuart, Lin Jianghai, Lee Sang Hong, Lambert Ann, Zhao Zhen Z, Roseman Fenella, Guo Qun, Gordon Scott D, Wallace Leanne, Henders Anjali K, Visscher Peter M, Kraft Peter, Martin Nicholas G, Morris Andrew P, Treloar Susan A, Kennedy Stephen H, Missmer Stacey A, Montgomery Grant W, Zondervan Krina T
Abstract excerpt
Endometriosis is a common gynecological disease associated with pelvic pain and subfertility. We conducted a genome-wide association study (GWAS) in 3,194 individuals with surgically confirmed endometriosis (cases) and 7,060 controls from Australia and the UK. Polygenic predictive modeling showed significantly increased genetic loading among 1,364 cases with moderate to severe endometriosis. The strongest...
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