Article

Dynamic phospho-proteogenomic analysis of gastric cancer cells suggests host immunity provides survival benefit

2024-02-07

Abstract excerpt

The mainstay of advanced gastric cancer (GC) therapy is DNA-damaging drugs. Using proteogenomic analysis of a panel of eight GC cell lines, we identified genetic alterations and signaling pathways, potentially associated with resistance to DNA-damaging drugs. Notably, 5-fluorouracil (5FU) resistance was associated with PD-L1 expression, but not established GC subtypes. In publicly available cohort data, PD-L1 expr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 09e17311-e81d-522c-98f8-46b86bd344d3
DOI: 10.1101/2024.02.06.24302407

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dynamic phospho-proteogenomic analysis of gastric cancer cells suggests host immunity provides survival benefitDOI 10.1101/2024.02.06.24302407Read

Signaling pathways and therapeutic interventions in gastric cancerSemantic proximity Read

Immunogenomics Analysis Reveals that TP53 Mutations Inhibit Tumor Immunity in Gastric CancerSemantic proximity Read

Molecular Profiling of Gastric Cancer: Toward Personalized Cancer MedicineSemantic proximity Read

An immune signature for risk stratification and therapeutic prediction in helicobacter pylori-infected gastric cancerSemantic proximity Read

Patient-Level DNA Damage Repair Pathway Profiles and Anti-Tumor Immunity for Gastric CancerSemantic proximity Read

Identification of gastric cancer subtypes based on pathway clusteringSemantic proximity Read

Novel DNA damage repair signature for immunotherapy and a proposed molecular subtyping scheme in gastric cancerSemantic proximity Read

Elevated neutrophil-to-lymphocyte ratio induced by tumor and immune cells promotes gastric cancer progression during PD-1 antibody-based treatmentSemantic proximity Read

Profiles of PD-1, PD-L1, PD-L2 in Gastric Cancer and Their Relation with Mutation, Immune Infiltration, and Survival.Semantic proximity Read

A 15-DNA Repair Gene Prognostic Signature for Immunotherapy in Gastric CancerSemantic proximity Read

Cellular heterogeneity and communication networks in gastric cancer: Single-cell analysis reveals β-hydroxybutyrylation-associated genes and immune infiltration characteristicsSemantic proximity Read

Identification of molecular features correlating with tumor immunity in gastric cancer by multi-omics data analysisSemantic proximity Read