Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Trifluridine/tipiracil overcomes the resistance of human gastric 5-fluorouracil-refractory cells with high thymidylate synthase expression

5 Feb 2018

Abstract excerpt

// Kazuaki Matsuoka 1 , Fumio Nakagawa 2 , Takashi Kobunai 1 and Teiji Takechi 1 1 Translational Research Laboratory, Taiho Pharmaceutical Co., Ltd., Tokushima, Japan 2 Applied Pharmacology Laboratory, Taiho Pharmaceutical Co., Ltd., Tokushima, Japan Correspondence to: Kazuaki Matsuoka, email: kazu-matsuoka@taiho.co.jp Keywords: trifluridine/tipiracil; TAS-102; 5-FU resistant cells; gastric cancer Received: June...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Cancer Treatments and Studies
Share to Gastric Cancer Management and Outcomes
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29568368
DOI: 10.18632/oncotarget.24412

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Trifluridine/tipiracil overcomes the resistance of human gastric 5-fluorouracil-refractory cells with high thymidylate synthase expressionPMID 29568368Read ↗

Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthaseSemantic proximity Read ↗

Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse modelsSemantic proximity Read ↗

Thymidine Kinase 1 Loss Confers Trifluridine Resistance without Affecting 5-Fluorouracil Metabolism and CytotoxicitySemantic proximity Read ↗

Different mechanisms of acquired resistance to fluorinated pyrimidines in human colorectal cancer cells.Semantic proximity Read ↗

Crucial roles of thymidine kinase 1 and deoxyUTPase in incorporating the antineoplastic nucleosides trifluridine and 2′-deoxy-5-fluorouridine into DNASemantic proximity Read ↗

Trifluridine Induces p53-Dependent Sustained G2 Phase Arrest with Its Massive Misincorporation into DNA and Few DNA Strand BreaksSemantic proximity Read ↗

MBD4frameshift mutation caused by DNA mismatch repair deficiency enhances cytotoxicity by trifluridine, an active antitumor agent of TAS-102, in colorectal cancer cellsSemantic proximity Read ↗

Results of a Randomized, Double-Blind, Placebo-Controlled, Phase III Trial of Trifluridine/Tipiracil (TAS-102) Monotherapy in Asian Patients With Previously Treated Metastatic Colorectal Cancer: The TERRA Study.Semantic proximity Read ↗

FOXM1 inhibitor, Siomycin A, synergizes and restores 5-FU cytotoxicity in human cholangiocarcinoma cell lines via targeting thymidylate synthaseSemantic proximity Read ↗

Molecular Mechanisms and Tumor Biological Aspects of 5-Fluorouracil Resistance in HCT116 Human Colorectal Cancer CellsSemantic proximity Read ↗

MicroRNA-330 inhibited cell proliferation and enhanced chemosensitivity to 5-fluorouracil in colorectal cancer by directly targeting thymidylate synthaseSemantic proximity Read ↗

Reduced Activity of Anabolizing Enzymes in 5‐Fluorouracil‐resistant Human Stomach Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.