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Article

The molecular determinants for distinguishing between ubiquitin and NEDD8 by USP2.

Scientific reports - 23 May 2017

Shin Yung-Cheng, Chen Jou-Han, Chang Shih-Chung

Abstract excerpt

Ubiquitin (Ub) shares the highest sequence identity with neuronal-precursor-cell-expressed developmentally downregulated protein-8 (NEDD8) in the Ub-like protein family. However, different enzyme systems are precisely employed for targeting Ub and NEDD8 to specific substrates. The molecular determinants for distinguishing between Ub and NEDD8 by Ub-specific peptidases (USPs) remain poorly characterized. By...

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Source

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Identifiers

PMID: 28536428
DOI: 10.1038/s41598-017-02322-x
PMCID: PMC5442100

Genes

NEDD8
USP2
USP21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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