Article
Association of Single-Nucleotide Polymorphism in the Hepcidin Promoter Gene with Susceptibility to Extrapulmonary Tuberculosis.
Genetic testing and molecular biomarkers - 1 Jun 2017
Liang Li, Liu Huijuan, Yue Jun, Liu Li-Rong, Han Min, Luo Liu-Lin, Zhao Yan-Lin, Xiao Heping
Abstract excerpt
BACKGROUND: Hepcidin is a 25-amino acid peptide produced by the liver in response to inflammation and iron overload. It is encoded by the hepcidin antimicrobial peptide (HAMP) gene and plays a key role in innate immunity. Previous studies have reported that a -582 A>G polymorphism in the HAMP promoter (HAMP-P) affects hepcidin expression, causing susceptibility to various bacterial and viral pathogens. However,...
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