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Article

The percentage of Epidermal Growth Factor Receptor (EGFR)-mutated neoplastic cells correlates to response to tyrosine kinase inhibitors in lung adenocarcinoma.

PloS one - 1 Jan 2017

de Biase Dario, Genestreti Giovenzio, Visani Michela, Acquaviva Giorgia, Di Battista Monica, Cavallo Giovanna, Paccapelo Alexandro, Cancellieri Alessandra, Trisolini Rocco, Degli Esposti Roberta, Bartolini Stefania, Pession Annalisa, Tallini Giovanni, Brandes Alba A

Abstract excerpt

BACKGROUND: Epidermal Growth Factor Receptor (EGFR) molecular analysis is performed to assess the responsiveness to Tyrosine Kinase Inhibitors (TKIs) in patients with Non-Small Cell Lung Cancer (NSCLC). The existence of molecular intra-tumoral heterogeneity has been observed in lung cancers. The aim of the present study is to investigate if the percentage of mutated neoplastic cells within the tumor sample might...

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Identifiers

PMID: 28520821
DOI: 10.1371/journal.pone.0177822
PMCID: PMC5433779

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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