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Article

Detection of an α-Globin Fusion Gene Using Real-Time Polymerase Chain Reaction-Based Multicolor Melting Curve.

Hemoglobin - 1 Nov 2020

Ju Ai-Ping, Jiang Fan, Li Jian, Tang Xue-Wei, Li Dong-Zhi

Abstract excerpt

Genetic recombination between homologous sequences on the human globin gene clusters can lead to the creation of fusion genes. In this study, we report the detection of an α-globin fusion gene by using real-time polymerase chain reaction (qPCR)-based multicolor melting curve analysis (MMCA). The carriers of this fusion gene had a mild α-thalassemia phenotype with a normal hemoglobin (Hb) value and borderline...

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PMID: 33148073
DOI: 10.1080/03630269.2020.1838923

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