Article
Comparison of antibody responses against Mycobacterium tuberculosis antigen Rv0679c in tuberculosis patients from the endemic and non-endemic regions of the Beijing genotype: a case control study.
BMC infectious diseases - 15 May 2017
Zhao Jingge, Matsuba Takashi, Zhang Xiaoyan, Leano Susan, Nakajima Chie, Chagan-Yasutan Haorile, Telan Elizabeth Freda, Suzuki Yasuhiko, Hattori Toshio
Abstract excerpt
BACKGROUND: Strains of the Beijing genotype of Mycobacterium tuberculosis (MTB) are reportedly associated with the virulence of tuberculosis (TB) infection, unfavorable outcomes of anti-TB treatment, and the global TB pandemic. Rv0679c, a hypothetical membrane protein related to host cell invasion, has a Beijing genotype-specific mutation at residue 142 (Asn142Lys). Antigenicity differences between Rv0679c-Asn142...
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