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Do Environmental Fluoride Exposure and ESRα Genetic Variation Modulate Methylation Modification on Bone Changes in Chinese Farmers?

Chemical research in toxicology - 19 Jun 2017

Zhang Yanli, Huang Hui, Gong Biao, Duan Leizhen, Sun Long, He Tongkun, Cheng Xuemin, Li Zhiyuan, Cui Liuxin, Ba Yue

Abstract excerpt

Although increasing evidence suggests that estrogen receptor α (ESRα) genetic variation could modify bone damage caused by environmental fluoride exposure, little is known about epigenetic mechanisms in relation to bone changes. A case-control study was conducted among farmers aged 18-55 years in Henan Province, China. X-ray was used to detect bone changes. Methylation status was determined by...

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PMID: 28505433
DOI: 10.1021/acs.chemrestox.7b00047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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