Molecular characterization of extraintestinal Escherichia coli isolates in Japan: relationship between sequence types and mutation patterns of quinolone resistance-determining regions analyzed by pyrosequencing.

doi:10.1128/JCM.03049-12

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Article

Molecular characterization of extraintestinal Escherichia coli isolates in Japan: relationship between sequence types and mutation patterns of quinolone resistance-determining regions analyzed by pyrosequencing.

Journal of clinical microbiology - 1 Jun 2013

Aoike Nozomi, Saga Tomoo, Sakata Ryuji, Yoshizumi Ayumi, Kimura Soichiro, Iwata Morihiro, Yoshizawa Sadako, Sugasawa Yasuyuki, Ishii Yoshikazu, Yamaguchi Keizo, Tateda Kazuhiro

Abstract excerpt

Infection from fluoroquinolone-resistant Enterobacteriaceae is an increasing health problem worldwide. In the present study, we developed a pyrosequencing-based high-throughput method for analyzing the nucleotide sequence of the quinolone resistance-determining regions (QRDRs) of gyrA and parC. By using this method, we successfully determined the QRDR sequences of 139 out of 140 clinical Escherichia coli...

Topics

Anti-Bacterial Agents
Cluster Analysis
DNA Gyrase
DNA Topoisomerase IV
Drug Resistance, Bacterial
Escherichia coli
Escherichia coli Infections
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Japan

Molecular Epidemiology

Multilocus Sequence Typing

Mutation, Missense

Phylogeny

Quinolones

Source

Open in PubMed Open full text

Identifiers

PMID: 23515543
DOI: 10.1128/JCM.03049-12
PMCID: PMC3716089

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23515543-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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