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VEGFA links self-renewal and metastasis by inducing Sox2 to repress miR-452, driving Slug

15 May 2017

Abstract excerpt

Cancer stem cells (CSC) appear to have increased metastatic potential, but mechanisms underlying this are poorly defined. Here we show that VEGFA induction of Sox2 promotes EMT and tumor metastasis. In breast lines and primary cancer culture, VEGFA rapidly upregulates SOX2 expression, leading to SNAI2 induction, EMT, increased invasion and metastasis. We show Sox2 downregulates miR-452, which acts as a novel...

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PMID: 28504716
DOI: 10.1038/onc.2017.4

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