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Article

WDR79/TCAB1 plays a conserved role in the control of locomotion and ameliorates phenotypic defects in SMA models.

Neurobiology of disease - 1 Sept 2017

Di Giorgio Maria Laura, Esposito Alessandro, Maccallini Paolo, Micheli Emanuela, Bavasso Francesca, Gallotta Ivan, Vernì Fiammetta, Feiguin Fabian, Cacchione Stefano, McCabe Brian D, Di Schiavi Elia, Raffa Grazia Daniela

Abstract excerpt

SMN (Survival Motor Neuron) deficiency is the predominant cause of spinal muscular atrophy (SMA), a severe neurodegenerative disorder that can lead to progressive paralysis and death. Although SMN is required in every cell for proper RNA metabolism, the reason why its loss is especially critical in the motor system is still unclear. SMA genetic models have been employed to identify several modifiers that can...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28502804
DOI: 10.1016/j.nbd.2017.05.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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