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Article

Survival motor neuron function in motor axons is independent of functions required for small nuclear ribonucleoprotein biogenesis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Oct 2006

Carrel Tessa L, McWhorter Michelle L, Workman Eileen, Zhang Honglai, Wolstencroft Elizabeth C, Lorson Christian, Bassell Gary J, Burghes Arthur H M, Beattie Christine E

Abstract excerpt

Spinal muscular atrophy (SMA) is a motor neuron degenerative disease caused by low levels of the survival motor neuron (SMN) protein and is linked to mutations or loss of SMN1 and retention of SMN2. How low levels of SMN cause SMA is unclear. SMN functions in small nuclear ribonucleoprotein (snRN...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP Response Element-Binding Protein

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Share to Ribonucleoproteins, Small Nuclear

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Source

Open in PubMed Open full text

Identifiers

PMID: 17065443
DOI: 10.1523/JNEUROSCI.1637-06.2006
PMCID: PMC6674655

Genes

SMN2
SMN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17065443-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Survival motor neuron function in motor axons is independent of functions required for small nuclear ribonucleoprotein biogenesis.PMID 17065443Read ↗

Zebrafish survival motor neuron mutants exhibit presynaptic neuromuscular junction defects.Semantic proximity Read ↗

Smn, the spinal muscular atrophy–determining gene product, modulates axon growth and localization of β-actin mRNA in growth cones of motoneuronsSemantic proximity Read ↗

A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects.Semantic proximity Read ↗

Targeting SR Proteins Improves SMN Expression in Spinal Muscular Atrophy CellsSemantic proximity Read ↗

Tissue-specific models of spinal muscular atrophy confirm a critical role of SMN in motor neurons from embryonic to adult stagesSemantic proximity Read ↗

Genome-wide identification of mRNAs associated with the protein SMN whose depletion decreases their axonal localizationSemantic proximity Read ↗

Axonal-SMN (a-SMN), a protein isoform of the survival motor neuron gene, is specifically involved in axonogenesisSemantic proximity Read ↗

Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor NeuronsSemantic proximity Read ↗

The SMN Complex at the Crossroad between RNA Metabolism and NeurodegenerationSemantic proximity Read ↗

Disease mechanisms and therapeutic approaches in spinal muscular atrophy.Semantic proximity Read ↗

A Role for SMN Exon 7 Splicing in the Selective Vulnerability of Motor Neurons in Spinal Muscular AtrophySemantic proximity Read ↗

Therapeutic strategies for spinal muscular atrophy: SMN and beyondSemantic proximity Read ↗

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