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Article

The TLR4-TRIF pathway can protect against the development of experimental allergic asthma.

Immunology - 1 Sept 2017

Shalaby Karim H, Al Heialy Saba, Tsuchiya Kimitake, Farahnak Soroor, McGovern Toby K, Risse Paul-Andre, Suh Woong-Kyung, Qureshi Salman T, Martin James G

Abstract excerpt

The Toll-like receptor (TLR) adaptor proteins myeloid differentiating factor 88 (MyD88) and Toll, interleukin-1 receptor and resistance protein (TIR) domain-containing adaptor inducing interferon-β (TRIF) comprise the two principal limbs of the TLR signalling network. We studied the role of these adaptors in the TLR4-dependent inhibition of allergic airway disease and induction of CD4+ ICOS+ T cells by nasal...

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Source

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Identifiers

PMID: 28502093
DOI: 10.1111/imm.12755
PMCID: PMC5543728

Genes

ICOS
TLR4
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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