Article
Genome-wide DNA Methylation Analysis Reveals GABBR2 as a Novel Epigenetic Target for EGFR 19 Deletion Lung Adenocarcinoma with Induction Erlotinib Treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2017
Niu Xiaomin, Liu Fatao, Zhou Yi, Zhou Zhen, Zhou Daizhan, Wang Ting, Li Ziming, Ye Xiangyun, Yu Yongfeng, Weng Xiaoling, Zhang Hong, Ye Junyi, Liao Meilin, Liu Yun, Chen Zhiwei, Lu Shun
Abstract excerpt
Purpose: The past decade has witnessed the rapid development of personalized targeted therapies in lung cancer. It is still unclear whether epigenetic changes are involved in the response to tyrosine kinase inhibitor (TKI) treatment in epidermal growth factor receptor (EGFR)-mutated lung cancer.Experimental Design: Methyl-sensitive cut counting sequencing (MSCC) was applied to investigate the methylation changes...
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