Article
Effects of maternal dexamethasone treatment early in pregnancy on glucocorticoid receptors in the ovine placenta.
Reproductive sciences (Thousand Oaks, Calif.) - 1 May 2015
Shang H, Meng W, Sloboda D M, Li S, Ehrlich L, Plagemann A, Dudenhausen J W, Henrich W, Newnham J P, Challis J R G, Braun T
Abstract excerpt
The effects of endogenous cortisol on binucleate cells (BNCs), which promote fetal growth, may be mediated by glucocorticoid receptors (GRs), and exposure to dexamethasone (DEX) in early pregnancy stages of placental development might modify this response. In this article, we have investigated the expression of GR as a determinant of these responses. Pregnant ewes carrying singleton fetuses (n = 119) were...
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