Article
Flow cytometric measurement of the cellular propagation of TDP-43 aggregation.
Prion - 4 May 2017
Zeineddine Rafaa, Whiten Daniel R, Farrawell Natalie E, McAlary Luke, Hanspal Maya A, Kumita Janet R, Wilson Mark R, Yerbury Justin J
Abstract excerpt
Amyotrophic lateral sclerosis is a devastating neuromuscular degenerative disease characterized by a focal onset of motor neuron loss, followed by contiguous outward spreading of pathology including TAR DNA-binding protein of 43 kDa (TDP-43) aggregates. Previous work suggests that TDP-43 can move between cells. Here we used a novel flow cytometry technique (FloIT) to analyze TDP-43 inclusions and propagation....
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