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Elucidation of a complete mechanical signaling and virulence activation pathway in enterohemorrhagic Escherichia coli

1 Apr 2022

Abstract excerpt

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is an important extracellular human pathogen. The initial adherence of EHEC to host cells is a major cue for transcriptional induction of the locus of enterocyte effacement (LEE) genes to promote colonization and pathogenesis, but the mechanism through which this adherence is sensed and the LEE is induced remains largely elusive. Here, we report a complete signal...

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PMID: 35385749
DOI: 10.1016/j.celrep.2022.110614

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