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Article

Identification of Neoantigens in Cancer Cells as Targets for Immunotherapy.

International journal of molecular sciences - 26 Feb 2022

Okada Masahiro, Shimizu Kanako, Fujii Shin-Ichiro

Abstract excerpt

The clinical benefits of immune checkpoint blockage (ICB) therapy have been widely reported. In patients with cancer, researchers have demonstrated the clinical potential of antitumor cytotoxic T cells that can be reinvigorated or enhanced by ICB. Compared to self-antigens, neoantigens derived from tumor somatic mutations are believed to be ideal immune targets in tumors. Candidate tumor neoantigens can be...

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Identifiers

PMID: 35269735
DOI: 10.3390/ijms23052594
PMCID: PMC8910406

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