Article
Advances in personalized neoantigen vaccines for cancer immunotherapy.
Bioscience trends - 4 Nov 2020
Sun Changbo, Xu Shun
Abstract excerpt
Immunotherapy, which targets T cell inhibitory receptors (immune checkpoints), is now being widely used to treat a variety of types of cancer combined with surgery, chemotherapy, or radiotherapy. However, immune checkpoint inhibitors are highly dependent on the ability to present diverse tumor antigens to T cells. Neoantigens, arising from somatic mutations and specifically targeting tumor cells, have the...
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