Article
Advances in personalized neoantigen vaccines for cancer immunotherapy.
Bioscience trends - 4 Nov 2020
Sun Changbo, Xu Shun
Abstract excerpt
Immunotherapy, which targets T cell inhibitory receptors (immune checkpoints), is now being widely used to treat a variety of types of cancer combined with surgery, chemotherapy, or radiotherapy. However, immune checkpoint inhibitors are highly dependent on the ability to present diverse tumor antigens to T cells. Neoantigens, arising from somatic mutations and specifically targeting tumor cells, have the...
Topics
- Antigens, Neoplasm
- Cancer Vaccines
- Humans
- Immunogenicity, Vaccine
- Immunotherapy
- Mutation
- Neoplasms
- Precision Medicine
- T-Lymphocytes
- Tumor Escape
- Vaccines, Subunit