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Article

USP4 interacts and positively regulates IRF8 function via K48-linked deubiquitination in regulatory T cells.

FEBS letters - 1 Jun 2017

Lin Ruirong, Nie Jia, Ren Jiazi, Liang Rui, Li Dan, Wang Ping, Gao Chengjiang, Zhuo Changhua, Yang Chunkang, Li Bin

Abstract excerpt

CD4+ CD25+ regulatory T (Treg) cells comprise a unique subset of T cells required for maintaining immune homeostasis. However, the molecular mechanisms associated with the functional variety of Treg cells are not fully delineated. In the present study, we demonstrate that ubiquitin-specific protease (USP)4 physically interacted with interferon regulatory factor 8 (IRF8) function via a K48-linked deubiquitinase,...

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Source

Identifiers

PMID: 28477415
DOI: 10.1002/1873-3468.12668

Genes

USP4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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