Article
Extracellular ubiquitin enhances the suppressive effects of regulatory T cells on effector T cell responses.
Clinical laboratory - 1 Jan 2014
Cao Yuezhen, Li Chengli, Zhang Qi, Wang Yuan, Xia Rong
Abstract excerpt
BACKGROUND: CD4+CD25+ FoxP3+ Regulatory T (Treg) cells have been proven to play important roles in immune homeostasis, especially immune tolerance, mainly by regulating the function of CD4+CD25- effector T (Teff) cells. As the reduced activity of Treg cells is closely related with autoimmune diseases, development of strategies for modulating the activity of Treg cells has become the focus of recent studies....
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