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Article

Structure aided design of a Neu5Gc specific lectin.

Scientific reports - 4 May 2017

Day Christopher J, Paton Adrienne W, Higgins Melanie A, Shewell Lucy K, Jen Freda E-C, Schulz Benjamin L, Herdman Brock P, Paton James C, Jennings Michael P

Abstract excerpt

Subtilase cytotoxin (SubAB) of Escherichia coli is an AB5 class bacterial toxin. The pentameric B subunit (SubB) binds the cellular carbohydrate receptor, α2-3-linked N-glycolylneuraminic acid (Neu5Gc). Neu5Gc is not expressed on normal human cells, but is expressed by cancer cells. Elevated Neu5Gc has been observed in breast, ovarian, prostate, colon and lung cancer. The presence of Neu5Gc is prognostically...

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Identifiers

PMID: 28473713
DOI: 10.1038/s41598-017-01522-9
PMCID: PMC5431456

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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