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Article

Increased efficiency of Campylobacter jejuni N-oligosaccharyltransferase PglB by structure-guided engineering.

Open biology - 1 Apr 2015

Ihssen Julian, Haas Jürgen, Kowarik Michael, Wiesli Luzia, Wacker Michael, Schwede Torsten, Thöny-Meyer Linda

Abstract excerpt

Conjugate vaccines belong to the most efficient preventive measures against life-threatening bacterial infections. Functional expression of N-oligosaccharyltransferase (N-OST) PglB of Campylobacter jejuni in Escherichia coli enables a simplified production of glycoconjugate vaccines in prokaryotic cells. Polysaccharide antigens of pathogenic bacteria can be covalently coupled to immunogenic acceptor proteins...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25833378
DOI: 10.1098/rsob.140227
PMCID: PMC4422122

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