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Article

A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes

3 May 2017

Abstract excerpt

Reprogramming has been shown to involve EMT-MET; however, its role in cell differentiation is unclear. We report here that in vitro differentiation of hESCs to hepatic lineage undergoes a sequential EMT-MET with an obligatory intermediate mesenchymal phase. Gene expression analysis reveals that Activin A-induced formation of definitive endoderm (DE) accompanies a synchronous EMT mediated by autocrine TGFβ...

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PMID: 28466868
DOI: 10.1038/ncomms15166

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