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Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans

26 Apr 2017

Abstract excerpt

The induction of mitochondrial biogenesis could potentially alleviate mitochondrial and muscle disease. We show here that dimethyl fumarate (DMF) dose-dependently induces mitochondrial biogenesis and function dosed to cells in vitro, and also dosed in vivo to mice and humans. The induction of mitochondrial gene expression is more dependent on DMF's target Nrf2 than hydroxycarboxylic acid receptor 2 (HCAR2). Thus,...

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PMID: 28460056
DOI: 10.1093/hmg/ddx167

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