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Article

The spinal muscular atrophy disease protein SMN is linked to the rho-kinase pathway via profilin

14 Sept 2011

Abstract excerpt

Spinal muscular atrophy (SMA), a frequent neurodegenerative disease, is caused by reduced levels of functional survival of motoneuron (SMN) protein. SMN is involved in multiple pathways, including RNA metabolism and splicing as well as motoneuron development and function. Here we provide evidence for a major contribution of the Rho-kinase (ROCK) pathway in SMA pathogenesis. Using an in vivo protein interaction...

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PMID: 21920940
DOI: 10.1093/hmg/ddr425

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