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Article

Degradation of a connexin40 mutant linked to atrial fibrillation is accelerated.

Journal of molecular and cellular cardiology - 1 Sept 2014

Gemel Joanna, Simon Adria R, Patel Dakshesh, Xu Qin, Matiukas Arvydas, Veenstra Richard D, Beyer Eric C

Abstract excerpt

Several Cx40 mutants have been identified in patients with atrial fibrillation (AF). We have been working to identify physiological or cell biological abnormalities of several of these human mutants that might explain how they contribute to disease pathogenesis. Wild type (wt) Cx40 or four different mutants (P88S, G38D, V85I, and L229M) were expressed by the transfection of communication-deficient HeLa cells or...

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Identifiers

PMID: 24973497
DOI: 10.1016/j.yjmcc.2014.06.010
PMCID: PMC4135452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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