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Article

Tumor Necrosis Factor Inhibits Spread of Hepatitis C Virus Among Liver Cells, Independent From Interferons.

Gastroenterology - 1 Aug 2017

Laidlaw Stephen M, Marukian Svetlana, Gilmore Rachel H, Cashman Siobhán B, Nechyporuk-Zloy Volodymyr, Rice Charles M, Dustin Lynn B

Abstract excerpt

BACKGROUND & AIMS: Tumor necrosis factor (TNF) is an inflammatory cytokine expressed by human fetal liver cells (HFLCs) after infection with cell culture-derived hepatitis C virus (HCV). TNF has been reported to increase entry of HCV pseudoparticles into hepatoma cells and inhibit signaling by interferon alpha (IFNα), but have no effect on HCV-RNA replication. We investigated the effects of TNF on HCV infection...

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Topics

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Share to Carcinoma, Hepatocellular
Share to Hepatitis C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocytes

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Share to Janus Kinases

Share to Liver Neoplasms

Share to Receptors, Tumor Necrosis Factor

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Source

Open in PubMed Open full text

Identifiers

PMID: 28456632
DOI: 10.1053/j.gastro.2017.04.021
PMCID: PMC5627365

Genes

TNF
IFNL1
IFNL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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