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Hepatitis C virus RNA replication is resistant to tumour necrosis factor-α

11 Apr 2003

Abstract excerpt

It was demonstrated using self-replicating hepatitis C virus (HCV) RNAs that both types of interferons (IFNs) (in particular IFN-alpha and IFN-gamma) are potent inhibitors of HCV replication in Huh-7 cells. Because IFN-gamma and tumour necrosis factor (TNF)-alpha trigger a partially overlapping set of antiviral defence mechanisms, it is tempting to speculate that TNF-alpha also inhibits HCV replication. However,...

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PMID: 12692291
DOI: 10.1099/vir.0.18997-0

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