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Article

Wright-Fisher exact solver (WFES): scalable analysis of population genetic models without simulation or diffusion theory.

Bioinformatics (Oxford, England) - 1 May 2017

Krukov Ivan, de Sanctis Bianca, de Koning A P Jason

Abstract excerpt

Motivation: The simplifying assumptions that are used widely in theoretical population genetics may not always be appropriate for empirical population genetics. General computational approaches that do not require the assumptions of classical theory are therefore quite desirable. One such general approach is provided by the theory of absorbing Markov chains, which can be used to obtain exact results by directly...

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PMID: 28453671
DOI: 10.1093/bioinformatics/btw802
PMCID: PMC5408789

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